While definitely not for novice users, Qubes is one of the top privacy-conscious distros. The graphical installer must be used to install the OS to your hard drive, which will be encrypted.
Qubes OS uses the Xen Hypervisor to run a number of virtual machines, compartmentalising your life into ‘personal’, ‘work’, ‘internet’ and so on for the sake of security. This means if you accidentally download malware on your work machine for instance, your personal files won’t be compromised.
The main desktop uses colour-coded windows to show different virtual machines, making it easy for you to tell them apart.